Blumberg Lab Publications

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Janesick, AS, Blumberg, B. (2016) Obesogens: an emerging threat to public health. Am J Obstet Gynecol, 214: 559-565 reprint in PDF format

Janesick, AS, Dimastrogiovanni, G, Vanek, L, Boulos, C, Chamorro-Garcia, R, Tang, W, Blumberg, B. (2016) On the Utility of ToxCast and ToxPi as Methods for Identifying New Obesogens. Environ Health Perspect., 124: 1214-1226  reprint in PDF format supplemental materials.

Pedram, A, Razandi, M, Blumberg, B, Levin, ER. (2016) Membrane and nuclear estrogen receptor alpha collaborate to suppress adipogenesis but not triglyceride content. FASEB J 30(1): 230-40. PMCID: 4684544 reprint in PDF format

Bavik, C, Henry, SH, Zhang, Y, Mitts, K, McGinn, T, Budzynski, E, Pashko, A, Lieu, KL, Zhong, S, Blumberg, B, Kuksa, V, Orme, M, Scott, I, Fawzi, A, Kubota, R. (2015) Visual Cycle Modulation as an Approach toward Preservation of Retinal Integrity. PLoS One 10(5): e0124940. PMCID: 4430241 reprint in PDF format.

Bergman, A, Becher, G, Blumberg, B, Bjerregaard, P, Bornman, R, Brandt, I, Casey, SC, Frouin, H, Giudice, LC, Heindel, JJ, Iguchi, T, Jobling, S, Kidd, KA, Kortenkamp, A, Lind, PM, Muir, D, Ochieng, R, Ropstad, E, Ross, PS, Skakkebaek, NE, Toppari, J, Vandenberg, LN, Woodruff, TJ, Zoeller, RT. (2015) Manufacturing doubt about endocrine disrupter science - A rebuttal of industry-sponsored critical comments on the UNEP/WHO report "State of the Science of Endocrine Disrupting Chemicals 2012". Regul Toxicol Pharmacol 73(3): 1007-17. reprint in PDF format.

Heindel, JJ, Vom Saal, FS, Blumberg, B, Bovolin, P, Calamandrei, G, Ceresini, G, Cohn, BA, Fabbri, E, Gioiosa, L, Kassotis, C, Legler, J, La Merrill, M, Rizzir, L, Machtinger, R, Mantovani, A, Mendez, MA, Montanini, L, Molteni, L, Nagel, SC, Parmigiani, S, Panzica, G, Paterlini, S, Pomatto, V, Ruzzin, J, Sartor, G, Schug, TT, Street, ME, Suvorov, A, Volpi, R, Zoeller, RT, Palanza, P. (2015) Parma consensus statement on metabolic disruptors. Environ Health 14(1): 54. PMCID: 4473834 reprint in PDF format.

Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. (2015) Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1): 54-64. PMCID: 4387200r  PMID:25680588. reprint in PDF format

Legler J, Fletcher T, Govarts E, Porta M, Blumberg B, Heindel JJ, Trasande L. (2015) Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European union. J Clin Endocrinol Metab 100(4): 1278-88. PMCID: 4399302r  PMID:25742518. reprint in PDF format

Janesick A, Wu SC, Blumberg B. (2015) Retinoic acid signaling and neuronal differentiation. Cell Mol Life Sci 72(8): 1559-76.  PMID:25558812. reprint in PDF format

Azuma K, Casey SC, Urano T, Horie-Inoue K, Ouchi Y, Blumberg B, Inoue S. (2015) Pregnane X receptor knockout mice display aging-dependent wearing of articular cartilage. PLoS One 10(3): e0119177. PMCID: 4352085r  PMID:25749104. reprint in PDF format

Blumberg B. (2014) Andres Carrasco (1946-2014). Dev Biol 393(1): 1-2.  PMID:25275141. reprint in PDF format

Chamorro-García R, Blumberg B. (2014) Transgenerational effects of obesogens and the obesity epidemic. Curr Opin Pharmacol 19: 153-158.  reprint in PDF format

Janesick, A.S., Shioda, T., and Blumberg, B. (2014) Transgenerational Inheritance of Prenatal Obesogen Exposure, Mol Cell Endocrinol., 398, 31-35. reprint in PDF format

Janesick, A., Schug, T.T., Heindel, J.J., and Blumberg, B. (2014) Environmental pollutants and obesity. in Bray, G., and Bouchard, C. editors. Handbook of Obesity - Volume 1: Epidemiology, Etiology, and Physiopathology, Third Edition, CRC Press, ISBN-10: 1842145568. pp 471-488 reprint in PDF format

Janesick A, Nguyen TT, Aisaki K, Igarashi K, Kitajima S, Chandraratna RA, Kanno J, Blumberg B. (2014) Active repression by RARγ signaling is required for vertebrate axial elongation. Development (Cambridge, England) 141(11) 2260-70.  PMID:24821986 reprint in PDF format

Kamstra JH, Hruba E, Blumberg B, Janesick A, Mandrup S, Hamers T, Legler J. (2014) Transcriptional and Epigenetic Mechanisms Underlying Enhanced in Vitro Adipocyte Differentiation by the Brominated Flame Retardant BDE-47. Environ Sci Technol 48(7): 4110-9. PMCID: 3983330r  PMID:24559133 reprint in PDF format

Goran MI, Dumke K, Bouret SG, Kayser B, Walker RW, Blumberg B. (2013) The obesogenic effect of high fructose exposure during early development. Nat Rev Endocrinol, 9(8): 494-500.  PMID:23732284. reprint in PDF format

Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. (2013) Reprint of "In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective". Toxicol Lett.  223(2): 260-7. PMCID: 3856224r  PMID:24107266. reprint in PDF format

Bergman A, Andersson AM, Becher G, van den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, Casey SC, Fowler PA, Frouin H, Giudice LC, Iguchi T, Hass U, Jobling S, Juul A, Kidd KA, Kortenkamp A, Lind M, Martin OV, Muir D, Ochieng R, Olea N, Norrgren L, Ropstad E, Ross PS, Ruden C, Scheringer M, Skakkebaek NE, Soder O, Sonnenschein C, Soto A, Swan S, Toppari J, Tyler CR, Vandenberg LN, Vinggaard AM, Wiberg K, Zoeller RT. (2013) Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors. Environ Health 12: 69. PMCID: 3765603r  PMID:23981490. reprint in PDF format

Janesick, A., Abbey, R., Liu, S., Taketani, M., and Blumberg, B. (2013) . ERF is a Retinoic Acid-Inducible Repressor Required for Primary Neurogenesis. Development 140, 3095-3106. reprint in PDF format supplemental material

Pueyo NC, Raub AG, Jackson S, Metz MM, Mount AC, Naughton KL, Eaton AL, Thomas NM, Hastings P, Greaves J, Blumberg B, Collins TJ, Sogo SG. (2013) Oxidation of Ethidium using TAML Activators: A Model for High School Research Performed in Partnership with University Scientists. J Chem Educ 90(3): 326-31. PMCID: 3622257  PMID:23585695 reprint in PDF format

Chamorro-García R, Sahu M, Abbey RJ, Laude J, Pham N, and Blumberg B. (2013) Transgenerational inheritance of prenatal obesogen exposure. Environ Health Perspect.121, 349-366. PMCID:3621201, PMID:23322813.  reprint in PDF format Supplemental material

Schug TT, Abagyan R, Blumberg B, Collins TJ, Crews D, DeFur PL, Dickerson SM, Edwards TM, Gore AC, Guillette LJ, Hayes T, Heindel JJ, Moores A, Patisaul HB, Tal TL, Thayer KA, Vandenberg LN, Warner JC, Watson CS, vom Saal FS, Zoeller RT, O'Brien KP, Myers JP. (2013) Designing endocrine disruption out of the next generation of chemicals. Green Chemistry. 15 , 181-198. reprint in PDF format

Li X, Pham HT, Janesick AS, andBlumberg B.(2012) Triflumizole is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPARgamma). Environ Health Perspect. 120, 1720-1726. reprint in PDF format, Supplemental Material

Chamorro-Garcia, R., Kirchner, S., Li, X., Janesick, A.S., Casey, S.C., Chow, C., and Blumberg, B. (2012) Bisphenol A Diglycidyl Ether Induces Adipogenic Differentiation of Multipotent Stromal Stem Cells Through a Peroxisome Proliferator Activated Receptor Gamma Independent Mechanism. Environ Health Perspect. 120, 7, 984-989. reprint in PDF format. Supplemental Material.

Hennig, B., Ormsbee, L., McClain, C.J., Watkins, B.A., Blumberg, B., Bachas, L.G., Sanderson, W., Thompson, C., and Suk, W.A. (2012) Nutrition Can Modulate the Toxicity of Environmental Pollutants: Implications in Risk Assessment and Human Health.  Environ Health Perspect. 120, 771-774. reprint in PDF format.

Boekelheide, K., Blumberg, B., Chapin, R.E., Cote, I., Graziano, J.H., Janesick, A., Lane, R., Lillycrop, K., Myatt, L., States, J.C., Thayer, K.A., Waalkes, M.P., and Rogers, J.M. (2012) Predicting later-Life Outcomes of Early-Life Exposures. Environ Health Perspect.120, 1353-1361. PMID:22672778. PMCID: 3491941. reprint in PDF format

Igarashi, S., Kitajima, S., Aisaki, K., Tanemura, K., Moriyama, N., Ikeno, E., Matsuda, N., Saga, Y., Blumberg, B., and Kanno, J. (2012)  Development of Humanized Steroid and Xenobiotic Receptor Mouse by Homologous Knock-in of the Human Steroid and Xenobiotic Receptor Ligand Binding Domain Sequence. J. Toxicol. Sci, 37, 373-380. reprint in PDF format.

Casey, S.C. and Blumberg, B. (2012) The Steroid and Xenobiotic Receptor Negatively Regulates B-1 Cell Development in the Fetal Liver. Molecular Endocrinology, 26, 916-926. reprint in PDF format. Supplemental material.

Janesick, A., and Blumberg, B. (2012) Obesogens, Stem Cells and the Developmental Programming of Obesity. Int. J. Andrology, 35, 437-448. reprint in PDF format.

Janesick, A., Shiotsugu, J., Taketani, M., and Blumberg, B. (2012) Ripply3 is a Retinoic Acid-Inducible Repressor Required for Setting the Borders of the Pre-placodal Ectoderm. Development, 139, 1213-1224. reprint in PDF format

Janesick A, Blumberg B. (2012) Adipocytes as Target Cells for Endocrine Disruption. In: Diamanti-Kandarakis E, Gore AC, editors. Endocrine Disrupters and Puberty. New York, NY: Humana Press/Springer;   2012. pp.255-271. reprint in PDF format

Schug, T.T., Janesick, A., Blumberg, B., Heindel, J.J. (2011)   Endocrine disrupting chemicals and disease susceptibility. J. Steroid Biochem. Mol. Biol.127, 204-215. reprint in PDF format

Casey, S. C., Nelson, E. L., Turco, G. M., Janes, M. R., Fruman, D. A. and Blumberg, B. (2011). B-1 Cell Lymphoma in Mice Lacking the Steroid and Xenobiotic Receptor, SXR. Mol Endocrinol. 25(6): 933-43. PMID: 21436254 reprint in PDF format Supplemental material.

Janesick AS, Blumberg B. (2011)  Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity. Embryo Today. Birth Defects Research (Part C). 93,34-50. reprint in PDF format.

Blumberg, B., Iguchi, T., Odermatt, A. (2011) Endocrine Disrupters. J. Steroid Biochem Molec Biol, 127, 1-3. reprint in PDF format

Li X, Ycaza J, Blumberg B. (2011) The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes. J Steroid Biochem Mol Biol, 127, 9-15. PMID 21397693.  reprint in PDF format

Janesick A, Blumberg B. (2011)  Minireview: PPARgamma as the target of obesogens. J Steroid Biochem Mol Biol., 127, 4-8.  PMID: 21251979. reprint in PDF format.

Janesick A, Blumberg B. (2011) The Role of Environmental Obesogens in the Obesity Epidemic. In: Lustig RH, editor. Obesity Before Birth: Springer US;. p.383-99. reprint in PDF format

Blumberg, B. (2011) Obesogens, Stem Cells, and the Maternal Programming of Obesity, Journal of Developmental Origins of Health and Disease, 2, 3-8.  reprint in PDF format

Azuma K, Casey SC, Ito M, Urano T, Horie K, Ouchi Y, Kirchner S, Blumberg B, Inoue S. (2010). Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption. J Endocrinol207, 257-263. PMID: 20876238. reprint in PDF format

Ellis WC, Tran CT, Roy R, Rusten M, Fischer A, Ryabov AD,Blumberg B, Collins TJ. (2010) Designing green oxidation catalysts for purifying environmental waters. J Am Chem Soc. 132,9774-81. PMCID: 2925145. PMID: 20565079. reprint in PDF format

Hellsten U., Harland R. M., Gilchrist M. J., Hendrix D., Jurka J., Kapitonov V., Ovcharenko I., Putnam N. H., Shu S., Taher L., Blitz I. L., Blumberg B., Dichmann D. S., Dubchak I., Amaya E., Detter J. C., Fletcher R., Gerhard D. S., Goodstein D., Graves T., Grigoriev I. V., Grimwood J., Kawashima T., Lindquist E., Lucas S. M., Mead P. E., Mitros T., Ogino H., Ohta Y., Poliakov A. V., Pollet N., Robert J., Salamov A., Sater A. K., Schmutz J., Terry A., Vize P. D., Warren W. C., Wells D., Wills A., Wilson R. K., Zimmerman L. B., Zorn A. M., Grainger R., Grammer T., Khokha M. K., Richardson P. M., Rokhsar D. S. (2010) The genome of the Western clawed frog Xenopus tropicalis. Science, 328, 633-636. reprint in PDF format

Chapman, J. A., Kirkness, E. F., Simakov, O., Hampson, S. E., Mitros, T., Weinmaier, T., Rattei, T., Balasubramanian, P. G., Borman, J., Busam, D., Disbennett, K., Pfannkoch, C., Sumin, N., Sutton, G. G., Viswanathan, L. D., Walenz, B., Goodstein, D. M., Hellsten, U., Kawashima, T., Prochnik, S. E., Putnam, N. H., Shu, S., Blumberg, B., Dana, C. E., Gee, L., Kibler, D. F., Law, L., Lindgens, D., Martinez, D. E., Peng, J., Wigge, P. A., Bertulat, B., Guder, C., Nakamura, Y., Ozbek, S., Watanabe, H., Khalturin, K., Hemmrich, G., Franke, A., Augustin, R., Fraune, S., Hayakawa, E., Hayakawa, S., Hirose, M., Hwang, J. S., Ikeo, K., Nishimiya-Fujisawa, C., Ogura, A., Takahashi, T., Steinmetz, P. R., Zhang, X., Aufschnaiter, R., Eder, M. K., Gorny, A. K., Salvenmoser, W., Heimberg, A. M., Wheeler, B. M., Peterson, K. J., Bottger, A., Tischler, P., Wolf, A., Gojobori, T., Remington, K. A., Strausberg, R. L., Venter, J. C., Technau, U., Hobmayer, B., Bosch, T. C., Holstein, T. W., Fujisawa, T., Bode, H. R., David, C. N., Rokhsar, D. S. and Steele, R. E. (2010). The dynamic genome of Hydra. Nature, 464, 592-6. PMID:20228792. reprint in PDF format

Kirchner, S., Kieu, T., Chow, C. Casey, S.C. and Blumberg, B. (2010). Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Molec. Endocrinol., 24, 526-539. reprint in PDF format

Grün, F., and Blumberg, B. (2009) The case for obesogens. Molec. Endocrinol., 23, 1127-1134. reprint in PDF format

Grün, F., and Blumberg, B. (2009) Endocrine disrupters as obesogens.Molecular and Cellular Endocrinology, 304, 19-29. reprint in PDF format

Zhou, C., Verma, S., Blumberg, B. (2009) The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl Recept Signal., 7, e001. reprint in PDF format

Verma, S., Tabb, M.M., and Blumberg, B. (2009) Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells. BMC Cancer 9:3. reprint in PDF format

Milnes, M.R., Garcia, A., Grossman, E., Grun, F., Shiotsugu, J., Tabb, M.M., Kawashima, Y., Katsu, Y., Watanabe, H., Iguchi, T., and Blumberg, B. (2008) Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and its orthologs in laboratory, toxicological and genome model species. Environ. Health. Perspect., 116, 880-885. reprint in PDF format

Iguchi, T., Watanabe, H., Ohta, Y., and Blumberg, B. (2008) Developmental effects: oestrogen induced vaginal changes and organotin induced adipogenesis. International Journal of Andrology, 31, 263-268. reprint in PDF format

Ichikawa, T., Horie-Inoue, K., Ikeda, K., Blumberg, B., and Inoue, S., (2007) Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J. Molec. Endocrinol., 39, 239-247. reprint in PDF format

Grün, F., and Blumberg, B. (2007) Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Reviews in Endocrinology and Metabolism, 8, 161-171. reprint in PDF format

Kumagai, J., Fujimura, T., Takahashi, S., Urano, T., Ogushi, T., Horie-Inoue, K., Ouchi, Y., Kitamura, T., Muramatsu, M., Blumberg, B. & Inoue, S. (2007). Cytochrome P450 2B6 is a growth-inhibitory and prognostic factor for prostate cancer. The Prostate 67, 1029-37. reprint in PDF format

Iguchi, T., Katsu, Y., Horiguchi, T., Watanabe, H., Blumberg, B. and Ohta, Y. (2007) Endocrine disrupting organotin comounds are potent inducers of imposex in gastropods and adipogenesis in vertebrates. Mol. Cell. Toxicol., 3, 1-10, 2007. reprint in PDF format

Zhou, C., Poulton, E. J., Grun, F., Bammler, T. K., Blumberg, B., Thummel, K. E., Eaton, D. L. (2007) The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol, 71, 220-229. reprint in PDF format

Mensah-Osman, E. J., Thomas, D. G., Tabb, M. M., Larios, J. M., Hughes, D. P., Giordano, T. J., Lizyness, M. L., Rae, J. M., Blumberg, B., Hollenberg, P. F.; Baker, L. H. (2007) Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer, 109, 957-965. reprint in PDF format

Grün, F., Watanabe, H., Zamanian, Z., Maeda, L., Arima, K., Chubacha, R., Gardiner, D.M., Iguchi, T., Kanno, J., and Blumberg, B. (2006) Endocrine disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol., 20, 2141-2155. reprint in PDF format

Ichikawa, T., Horie-Inoue, K., Blumberg, B., and Inoue, S. (2006) Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes and Collagen Accumulation in Osteoblastic Cells. J. Biol. Chem., 281, 16927-16934. reprint in PDF format

Zhou, C. Assem, M., Tay, J.C., Watkins, P.B., Blumberg, B., Schuetz, E.G., and Thummel, K.E. (2006) Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J. Clin. Invest. 116, 1703-1712. reprint in PDF format

Zhou C, Tabb MM, Nelson EL, Grun F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg, B. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J Clin Invest. 2006;116(8):2280-9. PMCID: 1501109. reprint in PDF format

Grün, F., and Blumberg, B. (2006) Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinology, 147, S50-S55. reprint in PDF format

Tabb, M.M., and Blumberg, B. (2006) New modes of action for endocrine-disrupting chemicals. Mol. Endocrinol. 20, 475-482. reprint in PDF format

Gunderson, M.P., Kohno, S., Blumberg, B., Iguchi, T., and Guillette, L.J. Jr. (2006) Induction of an alligator CYP3A gene by toxaphene and dexamethasone. Aquatic Toxicology, 78, 272-283. reprint in PDF format

Miki Y., Suzuki, T., Kitada, K., Yabuki, N., Shibuya, R., Moriya, T., Ishida, T., Ohuchi, N., Blumberg, B., and Sasano, H. (2006) Expression of the Steroid and Xenobiotic Receptor and Its Possible Target Gene, Organic Anion Transporting Polypeptide-A, in Human Breast Carcinoma. Cancer Research 66, 535-542. reprint in PDF format

Miki Y., Suzuki T., Tazawa C., Blumberg B., Sasano H. (2005) Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues. Mol Cell Endocrinol. 231, 75-85. reprint in PDF format

Arima, K., Shiotsugu, J., Niu, R., Khandpur, R., Martinez, M., Shin, Y., Koide, T., Cho, K.W.Y., Kitayama, A., Ueno, N., Chandraratna, R.A.S., and Blumberg, B. (2005) Global analysis of RAR-responsive genes in the Xenopus neurula using cDNA microarrays. Dev. Dyn., 232, 414-431. reprint in PDF format

Zhou, C., Tabb, M.M., Sadatrafiei, A., Grün, F., Sun, A., and Blumberg, B. (2004) Hyperforin, the Active Component of St. John's Wort, Induces IL-8 Gene Expression in Human Intestinal Epithelial Cells via a MAPK-dependent, NF-kB-independent Pathway, J. Clin. Immunol., 24, 623-636. reprint in PDF format

Zhou, C., Tabb, M.M., Sadatrafiei, A., Grün, F., and Blumberg, B. (2004) Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes. Drug Metabolism and Disposition 32, 1075-1082. reprint in PDF format

Shiotsugu, J., Katsuyama, Y., Arima, K., Baxter, A., Koide, T., Song, J., Chandraratna, R.A.S., and Blumberg, B. (2004) Multiple points of interaction between retinoic acid and FGF signaling during embryonic axis formation. Development, 131, 2653-2667. reprint in PDF format

Tabb, M.M., Kholodovych, V., Grün, F., Zhou, C., Welsh, W.J., and Blumberg, B. (2004) Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the Steroid and Xenobiotic Receptor (SXR). Environmental Health Perspectives, 112, 163-169. reprint in PDF format

Tabb, M.M., Sun, A., Errandi, J.L., Zhou, C., Grün, F., Romero, K., Inoue, S., and Blumberg, B. (2003) Vitamin K2 regulation of bone homeostasis is mediated by the orphan receptor, SXR. J. Biol. Chem. 278, 43919-43927. reprint in PDF format

Gardiner, D.M., Ndayibagira, A., Grün, F., and Blumberg, B. (2003) Deformed Frogs and Environmental Retinoids. Pure and Applied Chemistry 75, 2264-2273. reprint in PDF format

Peng, J., Riggs, B.L., Ogino, H., and Blumberg, B. (2003) Construction of a Set of Full-Length Enriched cDNA Libraries as Genomics Tools for Xenopus Tropicalis Research Current Genomics, 4, 635-644.. reprint in PDF format

Grün, F., and Blumberg, B. (2003). Use of Xenopus as a tool for orphan nuclear receptor characterization. Methods in Enzymology 364, 3-24. reprint in PDF format

Weston, A.D., Blumberg, B., and Underhill, T.M. (2003). Active repression by unliganded retinoid receptors in development: less is sometimes more. J. Cell Biol., 161, 223-228. reprint in PDF format

Zhou, C. and Blumberg, B. (2003) Overlapping Gene Structure of Human VLCAD and DLG4. Gene 305, 161-166. reprint in PDF format

Tabb, M.M., Zhou, C., and Blumberg, B. (2003) SXR and the Xenobiotic Response. In Toxicogenomics (T. Inoue, W.D. Pennie, Eds. Springer Verlag, Tokyo). reprint in PDF format

Grün, F., Venkatesan, R.N., Tabb, M.M., Zhou, C., Cao, J., Hemmati, D., and Blumberg, B. (2002). Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors. J. Biol. Chem. 277, 43691-43697. reprint in PDF format

Gabriel, W., Blumberg, B., Sutton, S., Place, A.R., and Lance, V.A. (2001)  Alligator aromatase cDNA sequence and its expression in embryos at male and female incubation temperatures. J. Exp. Zool., 290, 439-448. reprint in PDF format

Blumberg, B. (2001) Identification of Nuclear Hormone Receptor Homologs by Screening Libraries with Highly Degenerate Oligonucleotide Probes, Methods in Molecular Biology, 176, 119-129. reprint in PDF format

Koide, T., Downes, M., Chandraratna, R.A.S., Blumberg, B*. and Umesono, K. (2001) Active repression of RAR signaling is required for head formation. Genes Dev., 15, 2111-2121. reprint in PDF format *corresponding and senior author

Xie, W., Barwick, J. L., Simon, C. M., Pierce, A., Safe, S., Blumberg, B., Guzelian, P. S., and Evans, R. M. (2000). Reciprocal activation of target CYP genes by nuclear receptors SXR/PXR and CAR. Genes Dev., 14, 3014-3023. reprint in PDF format

Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., and Evans, R. M. (2000). Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 406, 435-439. reprint in PDF format

Tsukui, T. Capdevila, J., Yonei Tamura, S., Ruiz-Lozano, P., Rodriguez-Esteban,C., Tamura, K., Magallon, J., Chandraratna, R.A.S., Chien, K., Evans, R.M., Blumberg, B., and Izpisúa Belmonte, J.C. (1999). Multiple Left-right Asymmetry Defects in Shh -/- Mutant Mice Unveil a Convergence of the Shh and Retinoic Acid Pathways in the Control of Lefty-1. Proc. Natl. Acad. Sci. (U.S.A.), 96, 11376-11381. reprint in PDF format

Blumberg, B., and Izpisúa Belmonte, J. C. (1999) Subtractive hybridization and cDNA library construction. Methods in Molecular Biology 97, 555-574. reprint in PDF format

Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C., Ong, E.S., and Evans, R.M. (1998) SXR, a novel steroid and xenobiotic-activated nuclear hormone receptor. Genes Dev. 12, 3195-3205. reprint in PDF format

Blumberg, B. and Evans, R.M. (1998) Orphan nuclear receptors - New ligands and new possibilities. Genes Dev. 12, 3149-3155. reprint in PDF format

Ryan, A.K., Blumberg, B.*, Rodriguez-Esteban, C., Yonei-Tamura, S., Tamura, K., Tsukui, T., de la Pena, J., Sabbagh, W., Greenwald, J., Choe, S., Norris, D.P., Robertson, E.J., Evans, R.M., Rosenfeld, M.G., and Izpizua-Belmonte, J.C. (1998) Pitx2 determines left-right asymmetry of internal organs in vertebrates. Nature. 394, 545-552. reprint in PDF format *joint first authorship

Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A.G., Moreno, T.A., Umesono, K., Perlmann, T., De Robertis, E.M., and Evans, R.M. (1998) BXR, an embryonic orphan nuclear receptor activated by a novel class of endogenous benzoate metabolites. Genes Dev., 12, 1269-1277. reprint in PDF format

Pillemer, G., Epstein, M., Blumberg, B., Yisraeli, J.K., De Robertis, E.M., Steinbeisser, H., and Fainsod, A. (1997). Nested expression and sequential downregulation of the Xenopus caudal genes along the anterior-posterior axis. Mech. Dev. 71, 196-196. reprint in PDF format

Blumberg, B. (1997). An essential role for retinoid signaling in anteroposterior neural specification and neuronal differentiation. Seminars Cell Dev. Biol. 8, 417-428. reprint in PDF format

Bellefroid, E., Bourguignon, C., Bouwmeester, T., Rausch, O., Blumberg, B., Pieler, T. (1997) Transcription regulation and alternative splicing of an early zygotic gene encoding two structurally distinct zinc finger proteins in Xenopus laevis. Mech. Dev. 63, 99-108. reprint in PDF format

Blumberg, B., Bolado, J., Moreno, T.A., Kintner, C., Evans, R.M., and Papalopulu, N. (1997) An essential role for retinoid signaling in anteroposterior neural patterning, Development 124, 373-379. reprint in PDF format

Mullen, L.M., Bryant, S.V., Torok, M.A., Blumberg, B., and Gardiner, D.M. (1996) Nerve dependency of regeneration: the role of Distal-less and FGF signaling in amphibian limb regeneration. Development 122, 3487-3497. reprint in PDF format

Ackhar, C., Derguini, F., Blumberg, B., Langston, A., Levin, A., Speck, J., Evans, R.M., Bolado, J., Jr., Buck, J. and Gudas, L.J. (1996) 4-oxo-Retinol, a natural ligand and transactivator of the retinoic acid receptors. Proc. Natl. Acad. Sci. (USA) 93, 4891-4896. reprint in PDF format

Blumberg, B., Bolado, J., Derguini, F., Craig, A., Moreno, T.A., Chakravarti, D., Heyman, R.A., Buck, J., and Evans, R.M. (1996) Identification of novel retinoic acid receptor ligands from Xenopus. Proc. Natl. Acad. Sci. (USA) 93, 4873-4890. reprint in PDF format

Mangelsdorf, D.J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R.M. (1995) The nuclear receptor superfamily: The second decade. Cell 83, 835-839. reprint in PDF format

Hawlet, S., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M., Watabe, T., Blumberg, B., and Cho, K.W.Y. (1995) Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes Dev. 9, 2923-2935.

Greene, M.E., Blumberg, B., McBride, O.W., Yi, H.F., Kronquist, K., Kwan, K., Hsieh, L., Greene, G., and Nimer, S.D. (1995) Isolation of the human peroxisome proliferator activated receptor g cDNA: Expression in hematopoietic cells and chromosomal mapping. Gene Expression 4, 281-299.

Gardiner, D.M., Blumberg, B., Komine, Y., and Bryant, S.V. (1995) Regulation of HoxA expression in developing and regenerating axolotl limbs. Development 121, 1731-1741. reprint in PDF format

Nelson, R.E., Fessler, L.I., Takagi, Y., Blumberg, B., Keene, D.R., Olson, P.F., Parker, C.G., and Fessler, J.H. (1994) Peroxidasin: a novel enzyme-matrix protein of Drosophila development. EMBO J. 13, 3438-3447.

Forman, B.M., Chen, J., Blumberg, B., Kliewer, S.A., Henshaw, R., Ong, E.S., and Evans, R.M. (1994) Cross-talk among ROR a1 and the Rev-erb family of orphan nuclear receptors. Mol. Endocrinol. 8, 1253-1261. reprint in PDF format

Kliewer, S.A., Forman, B., Blumberg, B., Ong, E.S., Borgmeyer, U., Mangelsdorf, D.J., Umesono, K., and Evans, R.M. (1994) Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc. Natl. Acad. Sci. (USA) 91, 7355- 7359. reprint in PDF format

Gardiner D.M., Blumberg, B., Bryant, S.V. (1993) Expression of homeobox genes in limb regeneration. Progress in Clinical and Biological Research, 383A, 31-40.

Gont, L.K., Steinbeisser, H., Blumberg, B., and De Robertis, E.M. (1993) Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development 119, 991-1004. reprint in PDF format

Blum, M., Gaunt, S.J., Cho, K.W., Steinbeisser, H., Blumberg, B., Bittner, D., and De Robertis, E.M. (1992) Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106. reprint in PDF format

Blumberg, B., Mangelsdorf, D.J., Dyck, J., Bittner, D.A., Evans, R.M., and De Robertis, E.M. (1992) Multiple retinoid-responsive receptors in a single cell: families of RXRs and RARs in the Xenopus egg. Proc. Natl. Acad. Sci. (U.S.A.) 89, 2321-2325. reprint in PDF format

Cho, K.W.Y., Blumberg, B., and De Robertis, E.M. (1992) Cooperation between mesoderm-inducing growth factors and retinoic acid in Xenopus axis formation. (1991) Seminars in Developmental Biology 2, 393-403.

Cho, K.W.Y., Blumberg, B., Steinbeisser, H., and De Robertis, E.M. (1991) Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. Cell 67, 1111-1120. reprint in PDF format

Blumberg, B., Wright, C.V.E., De Robertis, E.M., and Cho, K.W.Y. (1991) Organizer- specific homeobox genes from Xenopus laevis embryos. Science 253, 194-196. reprint in PDF format

Saus, J., Quinones, S., MacKrell, A., Blumberg, B., Muthukumaran, G., Pihlajaniemi, T., and Kurkinen, M. (1989) The complete primary structure of mouse a2(IV) collagen: Alignment with mouse a1(IV) collagen. J. Biol. Chem. 264, 6318-6324. reprint in PDF format

Muthukumaran, G., Blumberg, B., and Kurkinen, M. (1989) The complete primary structure for the a1-chain of mouse collagen IV: Differential evolution of collagen IV domains. J. Biol. Chem. 264, 6310-6317. reprint in PDF format

Blumberg, B., MacKrell, A.J., and Fessler, J.H. (1988) Drosophila basement membrane procollagen a1(IV): II. Complete cDNA sequence, genomic structure and general implications for supramolecular assemblies. J. Biol. Chem. 263, 18328-18337. reprint in PDF format

MacKrell, A.J., Blumberg, B., Haynes, S., and Fessler, J.H. (1988) The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta-subunits. Proc. Natl. Acad. Sci. (U.S.A.) 85, 2633-2637. reprint in PDF format

Blumberg, B., MacKrell, A.J., Olson, P.F., Kurkinen, M., Monson, J.M., Natzle, J.E., and Fessler, J.H. (1987). Basement membrane procollagen IV and its specialized carboxyl domain are conserved in Drosophila, mouse, and human. J. Biol. Chem. 262, 5947-5950. reprint in PDF format

Kurkinen, M., Condon, M.R., Blumberg, B., Barlow, D., Quinones, S., Saus, J., and Pihlajaniemi, T. (1987). Extensive homology between the carboxyl-terminal peptides of mouse a1(IV) and a2(IV) collagen. J. Biol. Chem. 262, 8496-8499. reprint in PDF format

Blumberg, B., Fessler, L.I., Kurkinen, M., and Fessler, J.H. (1986). Biosynthesis and supramolecular assembly of procollagen IV in neonatal lung. J. Cell Biol. 103, 1711-1719. reprint in PDF format.


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